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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2110 | (+)-JQ-1 | JQ1 | Epigenetic Reader Domain , Autophagy , Ligands for Target Protein for PROTAC |
(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation. | |||
T5443 | JQ-1 (carboxylic acid) | JQ-1 carboxylic acid | Epigenetic Reader Domain |
JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2) | |||
T35412 | (+)-JQ-1-aldehyde | ||
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1]. | |||
T17311 | (+)-JQ1 PA | Epigenetic Reader Domain | |
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM). | |||
T10526 | β-NF-JQ1 | Others | |
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein inter... | |||
T19618 | (R)-(-)-JQ1 Enantiomer | Epigenetic Reader Domain | |
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay) | |||
T70702 | JQ1-Acid HCl | ||
(+)-JQ-1 carboxylic acid is a potent bromodomain and extra terminal domain (BET) inhibitor. (+)-JQ-1 carboxylic has potential to be used as a precursor to synthesize PROTACs and other conjugates. | |||
T16905 | SNIPER(BRD)-1 | Others | |
SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway an... |